Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016–2019)
نویسندگان
چکیده
منابع مشابه
Recent Trends in Archaeological Theory: Some Comments
This paper selectively reviews some recent themes in archaeological theory: a philosophical pragmatism, a turn to materiality, and understanding the past in the context of the present. It concludes with some reflective comments on the author’s Archaeological Theory: An Introduction, in advance of the third revised edition.
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Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD(50) along with 21 mg/kg atropine five min before the LD(50) of cyclosarin (120 ug/kg) was administered. Blood and bra...
متن کاملFrom the Research of Cholinesterase Reactivators to the Effective Therapy of Organophosphate/nerve Agent Poisoning
Nerve agents belong to the most toxic organophosphates (OP) in the group of cholinesterase inhibitors. They can be used as chemical warfare agents and, they can be (and were) misused by terrorists, as happened in Matsumoto city (1994) and Tokyo subway (1995). Sarin was used in these cases. Medical protection against their effect (i.e. antidotal treatment) is of prime importance (Bajgar 2004, 20...
متن کاملEffect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats
The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun. In this group there were some currently available oximes (obidoxime, trimedoxime and HI-6) and the rest were newly synthesized compounds. The best reactivation efficacy for acetylcholinesterase in blood (expressed as per...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2020
ISSN: 2218-273X
DOI: 10.3390/biom10030436